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Reduced cancer cell growth on chitosan surface

August 2019

A new paper published in the BJU International (Muratori et al., New basic insights on the potential of chitosan-based medical device for improving functional recovery after radical prostatectomy, DOI: 10.1111/bju.14834) has confirmed that chitosan significantly stimulates axon elongation from autonomic ganglia. Furthermore, the chitosan surface as well as the dissolution products of chitosan lead to a significantly lower proliferation rate of prostate cancer cell lines in vitro.

The authors could demonstrate, for the first time, a pro-regenerative effect of chitosan not only on somatic but also on autonomic neuronal ganglia. This observation is important since it provides a possible mechanistic explanation for the positive effects of a chitosan membrane on the functional recovery after radical prostatectomy, namely that the faster recovery of potency is due to the post-surgical stimulation of axonal regrowth in the peri-prostatic neurovascular bundles.

Moreover, given the intrinsic cell supportive capacity of chitosan, it is of great importance that a proliferative stimulation of prostate cancer cells after radical prostatectomy can be ruled out. Taken together, the results of this study provide strong evidence of the safety and efficacy of a chitosan membrane, from pre-clinical basic science models, underscoring the successful clinical results.